Category: Research Briefs
SGLT2 Drugs Reduced Heart-Failure and Kidney Events Across 14 Diabetes Trials
A meta-analysis of 14 placebo-controlled trials found lower relative risks of heart-failure hospitalization, cardiovascular death, and composite kidney outcomes with SGLT2 inhibitors in adults with type 2 diabetes.
Brown Fat Looked Promising—but Losartan Evidence Is Not Yet Human
A large retrospective imaging study linked greater brown-fat activity with favorable cardiometabolic patterns, while losartan activated brown fat only in cell and mouse experiments.
Continuous Glucose Monitoring Lowered HbA1c Without Insulin in a 283-Person Trial
A 26-week randomized trial found that continuous glucose monitoring improved HbA1c and time in range among adults with type 2 diabetes who were not using insulin.
Higher Paternal BMI Was Linked to Sperm DNA Methylation Differences
A human observational study links paternal BMI and age with sperm DNA methylation patterns, without proving effects on children.
Three Lab Values Were Linked to Mortality Risk—but the Score Is Not Yet Ready for Clinical Use
A large U.S. observational study linked the EASIX laboratory score with mortality, but it has not been validated for routine CKM risk screening.
Coffee Stayed Steady—but Creamer Added More Calories
A national analysis found stable coffee intake but rising calories from add-ins, led by non-dairy creamer.
High-Fiber Diet Outperformed Metformin in a Small Trial—but Don’t Replace Medication
A small randomized trial found better short-term HbA1c and BMI results with a prescribed high-fiber intervention than metformin alone, but important design limits prevent treatment conclusions.
Late-Night Eating Was Linked to Fatty Liver Disease—Not Proven to Cause It
A large observational analysis links habitual late-night eating with higher relative rates of fatty liver disease and cirrhosis, but it cannot establish cause and effect.
Peanuts Changed a Brain Insulin Signal—but Did Not Prove Dementia Protection
A small randomized crossover trial found a regional brain blood-flow response to insulin after 16 weeks of daily peanuts, but it did not establish dementia prevention or clinical…
Olive Oil Before Carbohydrates Slowed an Early Glucose Spike—in Mice
A new mouse study found that giving fat before glucose delayed gastric emptying and softened the early blood-sugar rise, but it does not establish a human treatment.
Potassium-Rich DASH Diet Appeared Safe With Common Blood-Pressure Medicines
A preliminary analysis of 356 adults found no dangerous potassium increase after three months of DASH-patterned groceries, but the result is not yet peer reviewed.
Nutrient-Dense Meals Lowered LDL—but Missed the Trial’s Main Outcomes
A 300-person randomized trial found no advantage on its primary endpoints, while LDL, blood-pressure and microbiome findings remained exploratory.