Tag: Onyx Pharmaceuticals Inc

Bristol-Myers drug fails liver cancer trial

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(Reuters) – Bristol-Myers Squibb Co on Thursday said its experimental drug brivanib failed in a late-stage trial to match Nexavar, a cancer treatment sold by Bayer AG and Onyx Pharmaceuticals Inc, in prolonging the lives of patients with advanced liver cancer The Bristol-Myers drug is an oral once-daily treatment that blocks receptors to VEGF, a protein involved in many cancers, and also blocks enzymes called FGFR tyrosine kinases that have been linked to cancer. The company said it will continue other trials of the medicine in kidney cancer and against other tumor types. …

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FDA staff focus on Onyx cancer drug’s side effects

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WASHINGTON (Reuters) – U.S. drug reviewers said the serious heart, lung and liver side effects of Onyx Pharmaceuticals Inc’s carfilzomib drug may outweigh the experimental drug’s benefits for patients with a type of blood cancer. The Food and Drug Administration staff said about 22 percent of people taking the drug during a key clinical trial responded to the medicine, and many had severe side effects, meaning carfilzomib may not be better than older treatments for multiple myeloma. …

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