Insight: Red flags ignored for years at firm in meningitis crisis

A sample of Aspergillus fumigatus, the first fungus diagnosed in the fungal meningitis outbreak sweeping the United States, in Nashville, TennesseeBOSTON (Reuters) – A cracked vial here, a missing label there. The complaints coming into New England Compounding Center, the firm at the heart of the deadly U.S. meningitis outbreak, were piling up. In March, regulators responded to a complaint from the prestigious Massachusetts Eye and Ear Infirmary about a potency concern involving one of the eye medications it purchased from NECC. The investigation is ongoing. Over the summer, physicians at Ruby Memorial Hospital in West Virginia returned a bag of cardioplegia solution used in heart surgery after a patient did not respond as expected. …

Baseball pitch counts don’t predict injuries: study

NEW YORK (Reuters Health) – It’s impossible to watch a Major League Baseball game nowadays – for example, the World Series now underway – without hearing about how many pitches a player has thrown. But a new study suggests that when it comes to preventing injuries, the obsession of many teams with those kinds of numbers may be misplaced. “I don’t necessarily think that pitch counts or innings pitched are the best way to measure the demands of pitching,” Thomas Karakolis, the lead author on the study, told Reuters Health. …

Did the Neurontin lawsuit fuel health spending?

NEW YORK (Reuters Health) – In 2004, Pfizer, the world’s largest drug company, agreed to plead guilty and pay more than $430 million to settle charges it had illegally marketed the epilepsy drug Neurontin for unapproved uses. Now, a study in the Journal of Clinical Psychiatry questions whether the lawsuit ended up fueling spending on other epilepsy drugs instead of curbing so-called off-label prescribing. Doctors are allowed to prescribe drugs for uses that haven’t been approved by U.S. health regulators, but companies are prohibited from marketing their products for such purposes. …

Meningitis death toll reaches 25 with another Tennessee fatality

A sample of Cladosporium species, one of the fungi diagnosed in the fungal meningitis outbreak sweeping the United States, in Nashville, Tennessee(Reuters) – The U.S. death toll from a meningitis outbreak tied to contaminated steroid injections reached 25 on Friday following another death in Tennessee, the state where the problem was first discovered, the Centers for Disease Control and Prevention said. In its daily update on the meningitis emergency, the CDC said the latest fatality brings the number of deaths to 10 in Tennessee, the most of any state. Michigan has reported five deaths, Florida and Indiana three each, Virginia two, and Maryland and North Carolina one each. …

FDA finds contaminants in drug linked to meningitis

(Reuters) – The U.S. Food and Drug Administration said on Friday it found “greenish black foreign matter” and other contaminants in an injectable steroid produced by the New England Compounding Center, the pharmacy at the heart of a deadly U.S. meningitis outbreak. It also found that vials from the same bin of the steroid contained what appeared to be a “white filamentous material,” according to the report released by the FDA following inspections of the facility in October. …

Trans fats raise cholesterol, not blood sugar

NEW YORK (Reuters Health) – Although trans fats raise your levels of “bad” cholesterol, they don’t appear to have lasting impacts on your blood sugar, according to a new review of the medical evidence. Researchers found that both blood sugar and insulin, the hormone that keeps blood sugar levels in check, were similar regardless of how much trans fat people ate. The link between trans fats and high cholesterol levels is widely accepted, but there have been conflicting results on the effect on blood sugar control, which is involved in diabetes. …

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