Portola’s drug reverses effect of blood thinner Xarelto

(Reuters) – Portola Pharmaceuticals Inc said its experimental drug met the main goal of reversing the effect of an anticoagulant drug in a late-stage study, sending the company’s shares up 11 percent in premarket trading. Data showed that an intravenous shot of the drug, andexanet alfa, immediately reversed the anticoagulation activity of Xarelto, developed by Johnson & Johnson and Bayer AG, in healthy volunteers aged 50-75 years. Further data on the study is expected in mid-2015, Portola said on Friday. …
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Sanofi, Regeneron cholesterol drug also effective in monthly doses

A logo is seen in front of the entrance at the headquarters of French drugmaker Sanofi in Paris(Reuters) – An experimental drug from Sanofi SA and Regeneron Pharmaceuticals was found to be effective in lowering "bad" cholesterol even when administered once every four weeks, instead of every two weeks. The drug, alirocumab, belongs to an emerging class of injectable drugs that block a naturally occurring protein called PCSK9, which inhibits the liver from expelling "bad" LDL cholesterol. These drugs, called PCSK9 inhibitors, are aimed at patients whose cholesterol levels do not fall enough despite the use of statins such as Pfizer Inc's Lipitor, and those who are unable to tolerate them. …

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5 Tips For New Runners

5 Tips For New RunnersA friend recently told me she noticed there seemed to be a fad people were jumping on — the running fad. At first I didn't like the sound of it because a fad is something that usually passes. But then I realized, with the obesity rate growing not only in adults but children as well, I see this fad as people's way of finding a way to fight…

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Argos HIV drug misses main goal in mid-stage study

(Reuters) – Argos Therapeutics Inc said its experimental drug to treat HIV failed to meet its main goal in a mid-stage study, sending the company’s shares down 27 percent in premarket trade. The main goal of the trial required the drug to lower the median viral load more than a placebo in HIV-infected patients after 12 weeks of interruption of antiretroviral therapy. (Reporting by Rosmi Shaji in Bengaluru; Editing by Savio D’Souza)
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